Dr.MAL PDT
Dr. MAL consists of MAL (Methyl Aminolevulinate HCI)
ingredients, used for photodynamic therapy(PDT)*.
As a therapy that destroys sebum and inflammation, which are the fundamental causes of troubled skin, it effectively manages troubled skin and helps recover skin conditions.
Principle
01
When a pore with inflammation absorbs the Dr.MAL(Methyl ALA), it is transformed into Pplx.
02
Photodynamic Therapy refers to the process of irradiating the light energy of a certain wavelength, followed by the application of a photosensitizer, which selectively permeates into the sebaceous glands and pores, on skin. It helps improve troubled skin.
03
As the light of a certain wavelength is irradiated, it destroys acne bacteria and sebaceous glands resulting in the reduced inflammation.
Main Ingredients
Methyl – ALA 13%
Panax Ginseng Callus Culture Extract
| Existing 5-ALA | VS | Dr.MAL |
|---|---|---|
| Water-soluble | Oil-soluble | |
| Non-effective absorption | Fast Absorption | |
| Potential side effects | Almost no side effects | |
| Severe pain | Almost no pain | |
| Affects daily living | No impact on daily living |
Effective for strengthening damaged skin barriers
Methyl – ALA 13%
| Existing 5-ALA | VS | Dr.MAL |
|---|---|---|
| Water-soluble | Oil-soluble | |
| Non-effective absorption | Fast Absorption | |
| Potential side effects | Almost no side effects | |
| Severe pain | Almost no pain | |
| Affects daily living | No impact on daily living |
Panax Ginseng Callus Culture Extract
Effective for strengthening damaged skin barriers
What is Dr.MAL?
Why Dr.MAL?
Methyl-ALA (MAL) minimizes the skin damage, pain which may occur during PDT. According to the reports by Wiegell and Wulf, MAL is reported to cause less pain, compared to ALA, while simultaneously having a short post-treatment waiting time with reduced PDT side effects, hence proven to be effective for treatment.
J Clin Aesthet Dermatol. 2009 February; 2(2): 44-47
Therapeutic and Aesthetic Uses of Photodynamic Therapy Part five of a five-part series ALA-PDT and MAL-PDT What Makes Them Different.
-Michael H.Gold,MD
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MAL, which consists of methyl derivative bound to ALA, shows greater prognosis than the existing ALA.
MAL-PDT showed a significantly greater effect in the improvement of troubled skin conditions when compared to ALA-PDT.
*Median reduction in numbers of inflammatory lesion counts from baseline.
J Am Acad Dermatol. 2006 Apr;54(4):647-51
Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate.
-Wiegell SR, Wulf HC.
Short Incubation Time
25-30min
Methyl-ALA (MAL) is oil-soluble, hence has a greater skin absorption rate when compared to the existing ALA.
The higher the level of concentration of MAL, the greater the amount of Porphyrins that are absorbed by the skin. Hence, the amount of Porphyrins absorbed is proportionate to the level of concentration of MAL.
Depth of porphyrin fluorescence in lesions
| 3h | 18h | |
|---|---|---|
| Lesion depth (mm) per dose of methyl 5-aminolevulinate : mean ± S.E. (range) | ||
| 16mg/g | 1.5±0.26(0.7-2.2)(5) | 1.0±0.09(0.8-1.2)(5) |
| 80mg/g | 1.6±0.21(1.0-2.0)(5) | 1.1±0.07(0.9-1.3)(5) |
| 160mg/g | 1.4±0.22(0.6-2.0)(6) | 1.2±0.16(0.9-1.9)(6) |
| Depth of porphyrin fluorescence (mm) mean ± S.E. (range) | ||
| 16mg/g | 0.7±0.18(0.0-1.0)(5) | 0.5±0.19(0.2-1.1)(5) |
| 80mg/g | 1.0±0.26(0.0-1.4)(5) | 1.0±0.11(0.6-1.3)(5) |
| 160mg/g | 1.3±0.21(0.6-2.0)(6) | 0.8±0.24(0.4-1.9)(6) |
| Relative depth of porphyrin fluorescence (%) | ||
| 16mg/g | 55.7±16.4(0-100)(5) | 52.0±19.7(16.7-100)(5) |
| 80mg/g | 61.5±17.5(0-100)(5) | 88.2±9.7(50-100)(5) |
| 160mg/g | 98.3±1.7(90-100)(6) | 66.9±14.9(25-100)(6) |
*Number of subjects measured.
J Photochem Photobiol B 62(3):140-5 (2001 Sep.)
Selective distribution of porphyrins in thick basal cell carcinoma after topical application of methyl 5-aminolevulinate
-Peng Q, Soler AM, Warloe T, et al.
Minimized Cell Damage
As the amount of Porphyrins absorbed within the healthy cells of MAL (1.7nmol/g) is lower than that of ALA (7.2nmol/g) approximately by 1/7, the skin damage caused by MAL-PDT could be considered to be less than the damage caused by ALA-PDT.
Porphyrip levels and distribution of prophyrin metabolites 6h after substrate application*
| Substrate | Total porphyrins (nmol/g protein) | |
|---|---|---|
| Normal Skin | No | 1.2±0.1 |
| ALA | 7.2±0.5 | |
| ALA-ME | 1.7±0.2 | |
| Solar Keratoses | No | 1.3±0.1 |
| ALA | 36.4±4.0* | |
| ALA-ME | 14.9±2.2 |
Photochem Photobiol 1998; 68:218-21
Preferential relative porphyrin enrichment in solar keratoses upon topical application of aminolevulinic acid methylester.
-Fritsch C, Homey B, Stahl W et al.
Simple Application
In case of using Methyl-ALA, merely conducting the LED irradiation leads to the same effects by IPL
The Korean society for acne research, 2011:41
Methyl aminolevulinate photodynamic therapy for acne : Red light vs. Intense pulsed light. Jong soo Hong, MD, Jae Yoon Jung, MD, Ji Young Yoon, BS, Dae Hun Suh, MD, PhD
-Fritsch C, Homey B, Stahl W, Lehmann P, Ruzicka T, Sies HTritsch C, Homey B, Stahl W et al. Peng Q, Soler Am, Warloe T, et al.
Post Dr.MAL Cleanser included
MAL Neutralizing solution inhibits the conversion into Pplx by neutralizing the remaining MAL and ALA on the skin surface.*
Post-Dr. MAL Cleanser minimizes the side effects that may be caused from the ALA remaining on skin.
* European Journal of Pharmaceutical Sciences, 1999 Jan;7(2):87-91. Stability of 5-aminolevulinic acid in aqueous solution. Elfsson B. Waillin I, Eksborg S, Rudaeus K, Ros AM, Ehrsson H.
How to use?
STEP 01Preparation
1. Cleansing
Peeling helps the absorption of Dr. MAL
2. Acne Extraction
STEP 02Photo Dynamic Therapy
1. Application of Dr. MAL
1 vial
2. Incubation 20~25 min
The process in which the MAL absorbed by skin binds with inflammatory cells and sebaceous cells. Prevent light by covering the entire face with a wrap then covering it with blackout towel.
3. Removal
of remaining Dr. MAL
Cleanse the areacompletely using a cleansing sponge
4. LED Irradiation 15~20 min
(RED Light 630nm)
PDT reaction; Absorbed Dr.MALsolution meets the LED Light source.
STEP 03Finishing
1. Post-Dr.Mal Cleanser
(3~5 times pumping) Post-Dr.Malhelps decompose the solution remaining on the skin surface. Gently rub with fingers for 3~5 minutes. It prevents tanning which could occur after PDT reaction.
2. Removal
Post-Dr.MAL Cleanser
Cleanse the area using a cleansing sponge.
3. Skin relief Cooling
& Regeneration
4. UV Prevention
PDT Incubation & LED Guideline
A total of 3~5 treatments
1 treatment every 2 weeks recommended
