The global medical aesthetics field continues to evolve with cutting-edge technologies that offer safer, more effective results. Among the most exciting advancements today is the use of exosomes—tiny, naturally occurring vesicles that deliver powerful regenerative signals deep into the skin. Once limited to stem-cell research, exosomes are now being integrated into modern skin rejuvenation protocols worldwide, helping to optimize delivery of active ingredients and unlock advanced skin recovery without invasive procedures.
betterfill EXO56+ is RIBESKIN’s innovative solution that redefines exosome treatments by harnessing the benefits of plant-derived exosomes. It uses exosomes derived from Centella Asiatica—a botanical powerhouse known for its healing and soothing properties—combined with seven additional botanical extracts, including Licorice Root, Green Tea, Rosemary, Scutellaria Baicalensis, Polygonum Cuspidatum Root, and Matricaria Flower. Added to this is Glutathione, a potent antioxidant, and Hydrolyzed Sodium Hyaluronate for hydration. Together, these ingredients provide a gentle yet highly effective source of regenerative signals suitable for even the most sensitive skin types.
The unique advantage of betterfill EXO56+ lies in how these plant exosomes transport key active ingredients deep into the dermis. In the activating solution, the formula is enriched with PDRN (Polydeoxyribonucleotide), which supports DNA repair and tissue regeneration; Coenzyme Q10, a well-known antioxidant that energizes skin cells and protects against environmental stress; Niacinamide, a multi-tasking B-vitamin that improves skin tone and strengthens the barrier; Epidermal Growth Factors (EGF), which stimulates new cell growth and accelerates wound healing; and Glutathione, which brightens skin and neutralizes free radicals.
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Exosomes work especially well when paired with advanced delivery methods such as microneedling. Microneedling creates micro-channels in the skin, allowing the plant-based exosomes and active ingredients to absorb more deeply. This helps deliver their full regenerative and antioxidant benefits more effectively, while keeping the treatment gentle and non-invasive for patients.
1. Anti-Oxidative & Pro-Regenerative Effect
Every day, the skin battles free radicals—unstable molecules generated by pollution, UV rays, and natural aging—that break down collagen and speed up visible aging. The antioxidant-rich blend in betterfill EXO56+ helps neutralize these free radicals, reducing oxidative stress at a cellular level. Ingredients like Coenzyme Q10 and Glutathione play a major role in this protective effect. Meanwhile, the exosomes act as couriers, delivering these antioxidants precisely where the skin needs them most.
Beyond protection, betterfill EXO56+ is engineered to help the skin rebuild itself. Ingredients like EGF and PDRN stimulate cell regeneration, boost collagen production, and accelerate skin renewal, giving skin a firmer, smoother, and healthier appearance.
2. Non-Invasive DNA Protection & Recovery
Skin damage begins at the cellular level—specifically within the DNA of skin cells. Over time, DNA damage caused by external aggressors leads to dullness, wrinkles, and weakened skin structure. PDRN, one of the star ingredients in betterfill EXO56+, supports DNA repair by providing building blocks that help damaged cells recover and regenerate more efficiently. This enhances the skin’s natural healing response, even after intensive treatments.
Discover some promising results from our clinical trials.
33.7% Skin Texture Improvement
21.1% Spot Reduction
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