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Medical AestheticRIBESKIN

Betterfill Collagen: A Precision Collagen Remodeling Solution

By 2026-02-27No Comments

Skin elasticity and smoothness depend on the integrity of collagen structures within the epidermis and upper dermis. Over time, intrinsic aging, UV exposure, and environmental stress lead to collagen fragmentation and structural disorganization. As collagen fibers weaken, fine wrinkles, surface unevenness, and reduced firmness begin to appear.

While many treatments temporarily fill lines or provide short-term hydration, true wrinkle improvement requires supporting the collagen matrix itself. Restoring the extracellular matrix (ECM) environment at a structural level allows the skin to regain resilience and elasticity from within.

To address fine wrinkles precisely, a professional solution designed for collagen remodeling is essential.

Betterfill Collagen: A Targeted ECM Remodeling System

RIBESKIN’s Betterfill Collagen is a professional solution specialized in collagen remodeling. It acts precisely from the epidermis to the upper dermis layer, supporting the restoration of damaged collagen structures within fine wrinkles rather than simply filling the skin.

Formulated with high-purity recombinant collagen and regenerative components, Betterfill Collagen delivers immediate hydration reinforcement while supporting long-term ECM restoration. This dual-action approach enables visible improvement shortly after treatment, followed by progressive elasticity enhancement over time.

What to Expect?

With structured professional sessions, skin demonstrates visible improvement in fine wrinkle appearance, smoothness, and elasticity. Hydration levels increase immediately after treatment, while continued ECM support promotes sustained firmness.

Clinical evaluation after four weekly sessions observed:

  • 63.9% reduction in recognized eye wrinkle density
  • 30.9% reduction in skin surface unevenness

These results reflect both immediate moisture reinforcement and progressive collagen remodeling support.

The Science Behind Betterfill Collagen

Recombinant Collagen III – 9,000 ppm
A soluble recombinant collagen produced through advanced bio-fermentation using yeast and bacteria-based systems. By introducing human collagen gene sequences into host cells, a non-animal collagen with high purity and safety is obtained.

Unlike conventional collagen ingredients that mainly provide surface-level effects, this functional recombinant collagen is designed to support restoration of the damaged collagen framework itself.

Sodium DNS – 5,000 ppm
Sodium DNA supports cellular recovery and promotes regeneration processes at the epidermal–dermal interface, contributing to improved skin resilience.

Sodium Hyaluronate
Provides immediate hydration reinforcement and strengthens the skin barrier, creating an optimal environment for collagen remodeling and ECM support.

Collagen Remodeling Technology

Betterfill Collagen is designed to support collagen remodeling from the epidermis to the upper dermis layer. By delivering functional collagen fragments enriched with active binding regions, it helps reinforce the structural organization of the extracellular matrix.

This technology offers:

Immediate hydration enhancement

Support for long-term ECM restoration

Progressive elasticity strengthening

Targeted fine wrinkle care

The focus is on structural support rather than temporary filling, aligning visible improvement with biological reinforcement.

Professional Application System

Betterfill Collagen is available in two professional formats:

Betterfill CollagenVialDeveloped for use with professional devices such as MTS, RF, and Laser systems. It allows controlled and precise delivery to targeted areas where fine wrinkles and elasticity concerns are most prominent.

Betterfill Collagen ShooterDesigned for use with the TURTLEPIN system, enabling even distribution and optimized absorption across the treatment area. Suitable for comprehensive fine wrinkle and elasticity care.

Each session typically includes cleansing, delivery using the selected system, and post-treatment soothing care to support barrier recovery.

Immediate Long Effects

Betterfill Collagen provides a dual-phase benefit:

Immediate phase: Noticeable hydration improvement and smoother skin appearance
Long-term phase: Gradual ECM reinforcement and sustained elasticity enhancement

This combined approach supports both short-term visible refinement and longer-term structural improvement.

In Conclusion

Fine wrinkles reflect underlying collagen structure disruption. Supporting meaningful skin rejuvenation requires reinforcing the extracellular matrix at a structural level.

Betterfill Collagen represents an advanced bio-fermented recombinant collagen technology designed for precise epidermis-to-upper dermis collagen remodeling. By combining immediate hydration reinforcement with long-term ECM support, it provides a comprehensive professional solution for fine wrinkle care and elasticity enhancement.

For Aesthetic Medicine:

Discover RIBESKIN’s aesthetic medicine treatments here, specially developed for dermatology and aesthetic clinics across the world.

If you are a dermatologist, aesthetic doctor, plastic surgeon, cosmetologist or distributor of aesthetic products, get in touch with us here

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Discover RIBESKIN’s professional beauty treatments here, specially developed for beauty salons and spas across the world.

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