Comparison of the efficacy of topical nicotinamide 4% vs topical clindamycin phosphate 1% gel in the treatment of inflammatory acne vulgaris. After 8 weeks of treatment, the topical nicotinamide is slightly superior to the clindamycin gel at reducing acne severity(A) and improving acne condition as assessed by the physician’s global evaluation (B)(n=38 per group; P not significant error not shown). Adapted with permission from shalita et al. Blackwell Publishing.