Dr.Mal

Principle

01
When a pore with inflammation absorbs the Dr.MAL(Methyl ALA), it is transformed into Pplx.

02
Photodynamic Therapy refers to the process of irradiating the light energy of a certain wavelength, followed by the application of a photosensitizer, which selectively permeates into the sebaceous glands and pores.

03
As the light of a certain wavelength is irradiated, it destroys acne bacteria and sebaceous glands resulting in the reduced inflammation.

Key Ingredients

Methyl – ALA 13%

Panax Ginseng Callus Culture Extract

Existing 5-ALA	VS	Dr.MAL
Water-soluble		Oil-soluble
Non-effective absorption		Fast Absorption
Potential side effects		Almost no side effects
Severe pain		Almost no pain
Affects daily activitys		No impact on daily activitys

Effective for strengthening damaged skin barriers

What is Dr.MAL?

Why Dr.MAL?

Methyl-ALA (MAL) minimizes the skin damage, pain which may occur during PDT. According to the reports by Wiegell and Wulf, MAL is reported to cause less pain, compared to ALA, while simultaneously having a short post-treatment waiting time with reduced PDT side effects, hence proven to be effective for treatment.

J Clin Aesthet Dermatol. 2009 February; 2(2): 44-47

Therapeutic and Aesthetic Uses of Photodynamic Therapy Part five of a five-part series ALA-PDT and MAL-PDT What Makes Them Different.
-Michael H.Gold,MD

High Satisfaction Level

MAL, which consists of methyl derivative bound to ALA, shows greater prognosis than the existing ALA.
MAL-PDT showed a significantly greater effect in the improvement of troubled skin conditions when compared to ALA-PDT.

*Median reduction in numbers of inflammatory lesion counts from baseline.

J Am Acad Dermatol. 2006 Apr;54(4):647-51

Photodynamic therapy of acne vulgaris using 5-aminolevulinic acid versus methyl aminolevulinate.
-Wiegell SR, Wulf HC.

Short Incubation Time
25-30min

Methyl-ALA (MAL) is oil-soluble, hence has a greater skin absorption rate when compared to the existing ALA.
The higher the level of concentration of MAL, the greater the amount of Porphyrins that are absorbed by the skin. Hence, the amount of Porphyrins absorbed is proportionate to the level of concentration of MAL.

Depth of porphyrin fluorescence in lesions

	3h	18h
Lesion depth (mm) per dose of methyl 5-aminolevulinate : mean ± S.E. (range)
16mg/g	1.5±0.26(0.7-2.2)(5)	1.0±0.09(0.8-1.2)(5)
80mg/g	1.6±0.21(1.0-2.0)(5)	1.1±0.07(0.9-1.3)(5)
160mg/g	1.4±0.22(0.6-2.0)(6)	1.2±0.16(0.9-1.9)(6)
Depth of porphyrin fluorescence (mm) mean ± S.E. (range)
16mg/g	0.7±0.18(0.0-1.0)(5)	0.5±0.19(0.2-1.1)(5)
80mg/g	1.0±0.26(0.0-1.4)(5)	1.0±0.11(0.6-1.3)(5)
160mg/g	1.3±0.21(0.6-2.0)(6)	0.8±0.24(0.4-1.9)(6)
Relative depth of porphyrin fluorescence (%)
16mg/g	55.7±16.4(0-100)(5)	52.0±19.7(16.7-100)(5)
80mg/g	61.5±17.5(0-100)(5)	88.2±9.7(50-100)(5)
160mg/g	98.3±1.7(90-100)(6)	66.9±14.9(25-100)(6)

*Number of subjects measured.

J Photochem Photobiol B 62(3):140-5 (2001 Sep.)

Selective distribution of porphyrins in thick basal cell carcinoma after topical application of methyl 5-aminolevulinate
-Peng Q, Soler AM, Warloe T, et al.

Minimized Cell Damage

As the amount of Porphyrins absorbed within the healthy cells of MAL (1.7nmol/g) is lower than that of ALA (7.2nmol/g) approximately by 1/7, the skin damage caused by MAL-PDT could be considered to be less than the damage caused by ALA-PDT.

Porphyrip levels and distribution of prophyrin metabolites 6h after substrate application*

	Substrate	Total porphyrins (nmol/g protein)
Normal Skin	No	1.2±0.1
	ALA	7.2±0.5
	ALA-ME	1.7±0.2
Solar Keratoses	No	1.3±0.1
	ALA	36.4±4.0*
	ALA-ME	14.9±2.2

Photochem Photobiol 1998; 68:218-21

Preferential relative porphyrin enrichment in solar keratoses upon topical application of aminolevulinic acid methylester.
-Fritsch C, Homey B, Stahl W et al.

Simple Application

In case of using Methyl-ALA, merely conducting the LED irradiation leads to the same effects by IPL

The Korean society for acne research, 2011:41

Methyl aminolevulinate photodynamic therapy for acne : Red light vs. Intense pulsed light. Jong soo Hong, MD, Jae Yoon Jung, MD, Ji Young Yoon, BS, Dae Hun Suh, MD, PhD
-Fritsch C, Homey B, Stahl W, Lehmann P, Ruzicka T, Sies HTritsch C, Homey B, Stahl W et al. Peng Q, Soler Am, Warloe T, et al.

Post Dr.MAL Cleanser included

MAL Neutralizing solution inhibits the conversion into Pplx by neutralizing the remaining MAL and ALA on the skin surface.*
Post-Dr. MAL Cleanser minimizes the side effects that may be caused from the ALA remaining on skin.

* European Journal of Pharmaceutical Sciences, 1999 Jan;7(2):87-91. Stability of 5-aminolevulinic acid in aqueous solution. Elfsson B. Waillin I, Eksborg S, Rudaeus K, Ros AM, Ehrsson H.

How to use?

STEP 01Preparation

1. Cleansing

Peeling helps the absorption of Dr. MAL

2. Acne Extraction

STEP 02Photo Dynamic Therapy (PDT)

1. Application of Dr. MAL

1 vial

2. Incubation 20~25 min

The process in which the MAL absorbed by skin binds with inflammatory cells and sebaceous cells. Block the light by cover the entire face with a wrap, followed by the dark colored towel.

3. Removal
of remaining Dr. MAL

Cleanse the area completely using a cleansing sponge.

4. LED Irradiation 15~20 min
(RED Light 630nm)

PDT reaction; Absorbed Dr.MALsolution meets the LED Light source.

STEP 03Finishing

1. Post-Dr.Mal Cleanser

(3~5 pumps) Post-Dr.Mal helps decompose the solution remaining on the skin surface. Gently rub with fingers for 3~5 minutes. It prevents tanning which could occur after PDT reaction.

2. Removal
Post-Dr.MAL Cleanser

Cleanse the area using a cleansing sponge.

3. Skin relief Cooling
& Regeneration

4. UV Prevention

Treatment Cycles

Total 3~5 treatments
1 treatment every 2 weeks

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Dr.MAL