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The original

Non-invasive CO2 Carboxy Therapy since 2007

As a revolutionary needle-free* CO2 Carboxy Therapy for professional use, RIBESKIN PRO CO2 Carboxy therapy is the best choice for maximization of the outcomes of dermatological and plastic surgery procedures. By accelerating skin metabolism via Bohr effect, not only the skin elasticity, tone and pore control are improved, but also bruises and swelling are alleviated while oil and moisture balance is controlled.
*Non-invasive CO2 Carboxy Therapy

What is CO2 Carboxy Therapy?

The original is different

RIBESKIN PRO CO2 Carboxy Combo is the first non-invasive CO2 Carboxy Therapy product for clinics and hospitals in Korea, which was developed exclusively by JMBIOTECH Corporation Limited in 2007. Trusted by over 300 million industry professionals from 38 countries around the world, it is manufactured, distributed and managed in adherence to strict standards.

The mechanism

What is the Bohr Effect?

When carbon dioxide is absorbed by skin cells from gel, hemoglobin in red blood cells release oxygen. This process provides oxygen to the skin while simultaneously stimulating the blood circulation, metabolism, protein synthesis and disposal of skin waste. These reactions reduce stretchmarks, cellulites, acne and inflammation while enhancing skin tone, elasticity and oil/moisture balance.


CO2 Carboxy Therapy

Instruction video

Instruction video

Please, click Plus (╋) button to watch the instruction video.

On face

On face

The original CO2 Carboxy Therapy for your face

Improved results of procedures are experienced without any irritation by consistently combining CO2 Carboxy Therapy with various dermatological and plastic surgery procedures such as laser, peeling, mesotherapy, postnatal skin care and etc.

*Non-invasive CO2 Carboxy Therapy

Wrinkle reduction

Transforms aged skin with wrinkles into elastic and youthful skin

Acne treatment

Accelerated blood flow and waste discharge effectively treats acne by recovering self-regenerative capacity of skin with anti-inflammatory properties

Lifting effects

Promotes protein synthesis and metabolism redefining sagging lines and enhancing skin elasticity


Effectively removes remaining waste and dead cells


Stimulates blood circulation and efficient removal skin waste creating translucent skin

Pore control

Enhances metabolism, removal of skin waste and contraction of pores

Treatment of bruise and swellings

Alleviates bruises and swellings created by various procedures by enhancing metabolism

On body

On Body

The original CO2 Carboxy Therapy for your body

CO2 Carboxy Therapy Body helps redefine body contours by dramatically improving skin elasticity and cellulite reduction with CO2 that is 3 times higher than the facial and neck sheet. It comes as a roll sheet which may be conveniently customized for each body part.

Cellulite reduction

Improves the elasticity of the loose and lumpy skin caused by diet

Stretch marks

Effectively removes stretch marks created after pregnancy or diet

Swell management

Effectively removes swellings of calves and feet from long hours of physical activities

Improvement of skin tone

Brightens the skin tone of the areas which easily become dark such as armpits and groins

Removal of skin waste

Effectively removes skin waste of oily-combination skin (back, forearm and etc.) which easily produces waste


Improves the elasticity of aged skin with wrinkles

Clinical result

Official clinical study

Skin brightening (1 procedure)1)

Pore control (1 procedure)2)

Facial Lifting (1 procedure)3)

Improvement Rate of Abdomen Epidermis Elasticity4)

No Irritancy to human skin5)

1) 1.06% improvement rate in skin brightening, a study on the application of CARBOXY CO2 GEL MASK PACK on human body for improvement in skin brightening, facial lifting and pore control, Ellead Co., Ltd., 2010.
2) 9.46% improvement rate in pore control, a study on the application of CARBOXY CO2 GEL MASK PACK on human body for improvement in skin brightening, facial lifting and pore control, Ellead Co., Ltd., 2010.
3) 3.73% improvement rate in lifting, a study on the application of CARBOXY CO2 GEL MASK PACK on human body for improvement in skin brightening, facial lifting and pore control, Ellead Co., Ltd., 2010.
4) 13.80% improvement rate in Abdomen Epidermis Elasticity, a Clinical test of CO2 CARBOXY COMBO Abdomen Epidermis Elasticity Improvement Clinical Evaluation, Korea Dermatology Research Institute, 2021
5) No Irritancy to human skin in Human Skin Compatibility Evaluation of CO2 CARBOXY COMBO, Korea Dermatology Research Institute, 2021

Internal case study

Acne treatment (Woman in mid 20s / 12 procedures, 12 weeks)

Radiance & brightness (woman in early 50 / 1 procedure)

wrinkles (woman in late 50 / 4 procedure, 4 weeks)

Wrinkles (woman in late 40 / 4 procedure, 4 weeks)

swelling & elasticity (woman in late 40 / 2 procedure)

stretch marks (woman in mid 40 / 5 procedure)

slimming (woman in mid 40 / 1 procedure)

wrinkles in hands (woman in mid 50 / 12 procedures, 12 weeks)

wrinkleds in hands (woman in mid 50 / 1 procedure)

wrinkles in hands (woman in mid 30 / 1 procedure)

stretch marks & elasticity (woman in mid 40 / 1 procedure)

Program Guidelines

Program Guidelines

Medical Aesthetic

When ‘an even better procedure’ is desired?

Plastic Surgery

When concerned about ‘post-procedure bruise and swelling care’?

CO2 Carboxy Therapy

When ‘an exclusive use of CO2 Carboxy Therapy’ is desired?


When a more effective ‘lipolysis procedure’ is desired?

Pre&Post Natal

CARBOXY COMBO suitable ‘even during pregnancy!’

Recommended Post-procedure



01 I see redness on my face after the RIBESKIN CO2 Carboxy Therapy.

Redness is one of the common outcomes but it does not mean your skin is irritated. The redness is due to the Bohr effect where the large amount of CO2 increases the partial pressure of the oxygen and the overall blood circulation. You will see more redness on those parts with poorer circulation of the fluids. This is like how your face turns red after an aerobic workout.

02 Is it safe to apply during pregnancy?

RIBESKIN CO2 Carboxy Therapy has been used for 80 years without reported side effects. It is a non-invasive (needleless) procedure having a minimal stimulus on skin, therefore, can be used during pregnancy.

03 Can I combine the MTS on face?

Yes, the MTS procedure can be combined. However, please make sure the RIBESKIN CO2 Carboxy Therapy is done before the light MTS procedure in order to maximize the absorption of the ampule. If the MTS is done before, some irritation on skin may be caused from the micro injuries from the MTS procedure.

04 Does it have a peeling effect?

There will be no intended peeling effect but oxygen bubbles are created from the CO2 generation. This may help with regeneration of the skin and removal of the dead skin making your skin looks smoother.

05 Is it OK to use any type of cleansing product before RIBESKIN CO2 Carboxy Combo?

Since CO2 is a carbonic acid, the strong acidic products that contain Vitamin C, Ascorbic Acid etc. may react to the CO2 gel and irritate the skin. Apart from those acidic products, avoid using cleansing or exfoliating products containing AHA or BHA.

06 In case of body therapy, is it OK to do CO2 Carboxy therapy before Microneedling?

It is OK to do CO2 Carboxy therapy right after the MTS. Since the RIBESKIN CO2 Carboxy therapy will enhance skin regeneration, apply MTS first on stretch marks before the Carboxy therapy. However, in case it is the first time for the client to have the Carboxy therapy, sole RIBESKIN CO2 Carboxy therapy is recommended without MTS since the MTS may cause some marks.
Apply the MTS once a week and RIBESKIN CO2 Carboxy therapy 2~3 times a week.

07 What to do with the remaining gel on the face?

Do not pat the remaining gel or let them absorbed into the skin. Wipe them out completely using a warm wet towel or sponges.